WWOX Polyclonal Antibody for Human(Homo sapiens) | EIAab.comWWOX Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > WWOX(Gene name) > Human

WWOX (Gene name),

WW domain-containing oxidoreductase (Protein name ), WWOX_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

WWOX(FOR;WOX1);

Protein name:

WW domain-containing oxidoreductase;

Alternative:

Fragile site FRA16D oxidoreductase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with COTE1/C1orf2 and SCOTIN. Interacts with TNK2.

Function:

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Subcellular Location:

Cytoplasm Nucleus Mitochondrion Golgi apparatus Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus.

Protein Attributes:

Sequence length:

414

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

414:

SERLIQERLG | SQSG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9NZC7

String:

Q9NZC7

Pfam:

PF00106

KEGG:

hsa:51741

MIM:

133239

UniGene:

Hs.461453

Uniprot:

Q9NZC7

FOR

ELISA Kit for Human WW domain-containing oxidoreductase

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E2982h

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96T

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ELISA Kit for Human WW domain-containing oxidoreductase

Cat.:

E2982c

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96T

ELISA Kit for Human WW domain-containing oxidoreductase

Cat.:

E2982m

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96T

CLIA Kit for Human WW domain-containing oxidoreductase

Cat.:

U2982h

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Packing:

96T

CLIA Kit for Human WW domain-containing oxidoreductase

Cat.:

U2982c

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MSDS:

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Packing:

96T

CLIA Kit for Human WW domain-containing oxidoreductase

Cat.:

U2982m

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Packing:

96T

Polyclonal Antibody for Human WW domain-containing oxidoreductase

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P2982Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human WW domain-containing oxidoreductase

Cat.:

P2982Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human WW domain-containing oxidoreductase

Protein for Human WW domain-containing oxidoreductase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer."
Bednarek A.K. , Laflin K.J. , Daniel R.L. , Liao Q. , Hawkins K.A. , Aldaz C.M.
Cancer Res.60:2140-2145(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35;TISSUE SPECIFICITY
tissue: Placenta.
2.

"Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells."
Ried K. , Finnis M. , Hobson L. , Mangelsdorf M. , Dayan S. , Nancarrow J.K. , Woollatt E. , Kremmidiotis G. , Gardner A. , Venter D. , Baker E. , Richards R.I.
Hum. Mol. Genet.9:1651-1663(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-414
3.

"WWOX, the FRA16D gene, behaves as a suppressor of tumor growth."
Bednarek A.K. , Keck-Waggoner C.L. , Daniel R.L. , Laflin K.J. , Bergsagel P.L. , Kiguchi K. , Brenner A.J. , Aldaz C.M.
Cancer Res.61:8068-8073(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6);FUNCTION;TISSUE SPECIFICITY
4.

"WWOX: a candidate tumor suppressor gene involved in multiple tumor types."
Paige A.J.W. , Taylor K.J. , Taylor C. , Hillier S.G. , Farrington S. , Scott D. , Porteous D.J. , Smyth J.F. , Gabra H. , Watson J.E.V.
Proc. Natl. Acad. Sci. U.S.A.98:11417-11422(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1; 3 AND 7);VARIANTS LEU-98; SER-111; TRP-120; THR-179; PHE-272; ALA-282 AND HIS-314;DISEASE
5.

"Cloning of human WOX8 (WWOX v8)."
Chang N.-S.
Submitted (2004-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-179
tissue: Colon adenocarcinoma.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue: Lung.
9.

"An opposing view on WWOX protein function as a tumor suppressor."
Watanabe A. , Hippo Y. , Taniguchi H. , Iwanari H. , Yashiro M. , Hirakawa K. , Kodama T. , Aburatani H.
Cancer Res.63:8629-8633(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
10.

"JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."
Chang N.-S. , Doherty J. , Ensign A.
J. Biol. Chem.278:9195-9202(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8 AND TP53;MUTAGENESIS OF LYS-28; ASP-29 AND TYR-33
11.

"Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma."
Park S.-W. , Ludes-Meyers J. , Zimonjic D.B. , Durkin M.E. , Popescu N.C. , Aldaz C.M.
Br. J. Cancer91:753-759(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
12.

"Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor."
Aqeilan R.I. , Palamarchuk A. , Weigel R.J. , Herrero J.J. , Pekarsky Y. , Croce C.M.
Cancer Res.64:8256-8261(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TFAP2C AND TFAP2A;DOMAIN
13.

"The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis."
Kuroki T. , Yendamuri S. , Trapasso F. , Matsuyama A. , Aqeilan R.I. , Alder H. , Rattan S. , Cesari R. , Nolli M.L. , Williams N.N. , Mori M. , Kanematsu T. , Croce C.M.
Clin. Cancer Res.10:2459-2465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
14.

"Loss of WWOX expression in gastric carcinoma."
Aqeilan R.I. , Kuroki T. , Pekarsky Y. , Albagha O. , Trapasso F. , Baffa R. , Huebner K. , Edmonds P. , Croce C.M.
Clin. Cancer Res.10:3053-3058(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
15.

"WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins."
Ludes-Meyers J.H. , Kil H. , Bednarek A.K. , Drake J. , Bedford M.T. , Aldaz C.M.
Oncogene23:5049-5055(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LITAF; WBP1; FAM189B AND SCOTIN;MUTAGENESIS OF 44-TRP--PRO-47 AND 85-TYR--PRO-88;DOMAIN;SUBCELLULAR LOCATION
16.

"Functional association between Wwox tumor suppressor protein and p73, a p53 homolog."
Aqeilan R.I. , Pekarsky Y. , Herrero J.J. , Palamarchuk A. , Letofsky J. , Druck T. , Trapasso F. , Han S.-Y. , Melino G. , Huebner K. , Croce C.M.
Proc. Natl. Acad. Sci. U.S.A.101:4401-4406(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP73;DOMAIN;MUTAGENESIS OF TYR-33 AND TYR-61;PHOSPHORYLATION AT TYR-33;SUBCELLULAR LOCATION
17.

"WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function."
Aqeilan R.I. , Donati V. , Palamarchuk A. , Trapasso F. , Kaou M. , Pekarsky Y. , Sudol M. , Croce C.M.
Cancer Res.65:6764-6772(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ERBB4
18.

"Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox."
Mahajan N.P. , Whang Y.E. , Mohler J.L. , Earp H.S.
Cancer Res.65:10514-10523(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-287 BY TNK2;UBIQUITINATION;MUTAGENESIS OF TYR-287;INTERACTION WITH TNK2
19.

"WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53."
Chang N.-S. , Doherty J. , Ensign A. , Schultz L. , Hsu L.-J. , Hong Q.
J. Biol. Chem.280:43100-43108(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MDM2 AND TP53;PHOSPHORYLATION;SUBCELLULAR LOCATION
20.

"WWOX gene restoration prevents lung cancer growth in vitro and in vivo."
Fabbri M. , Iliopoulos D. , Trapasso F. , Aqeilan R.I. , Cimmino A. , Zanesi N. , Yendamuri S. , Han S.-Y. , Amadori D. , Huebner K. , Croce C.M.
Proc. Natl. Acad. Sci. U.S.A.102:15611-15616(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
21.

"Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."
Hsu L.-J. , Schultz L. , Hong Q. , Van Moer K. , Heath J. , Li M.-Y. , Lai F.-J. , Lin S.-R. , Lee M.-H. , Lo C.-P. , Lin Y.-S. , Chen S.-T. , Chang N.-S.
J. Biol. Chem.284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-33;SUBCELLULAR LOCATION;INTERACTION WITH HYAL2
22.

"Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein."
Bouteille N. , Driouch K. , Hage P.E. , Sin S. , Formstecher E. , Camonis J. , Lidereau R. , Lallemand F.
Oncogene28:2569-2580(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH DVL1; DVL2 AND DVL3
23.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12 AND SER-14;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
24.

"A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma."
Takeuchi T. , Adachi Y. , Nagayama T.
Carcinogenesis33:548-554(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMEM207
25.

"The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration."
Abdel-Salam G. , Thoenes M. , Afifi H.H. , Koerber F. , Swan D. , Bolz H.J.
Orphanet J. Rare Dis.9:12-12(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SCAR12
26.

"Solution structure of the second WW domain of WWOX."
Kowalski K. , Merkel A.L. , Colella A. , Richards R.I. , Booker G.W.
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 51-101
27.

"Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma."
Kuroki T. , Trapasso F. , Shiraishi T. , Alder H. , Mimori K. , Mori M. , Croce C.M.
Cancer Res.62:2258-2260(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-291
28.

"The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation."
Mallaret M. , Synofzik M. , Lee J. , Sagum C.A. , Mahajnah M. , Sharkia R. , Drouot N. , Renaud M. , Klein F.A. , Anheim M. , Tranchant C. , Mignot C. , Mandel J.L. , Bedford M. , Bauer P. , Salih M.A. , Schuele R. , Schoels L. , more...
Brain137:411-419(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCAR12 THR-47 AND ARG-372

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